Smart Pills: Do they really exist?
28 January 2020
According to the Alzheimer’s Research & Prevention Foundation, regular physical exercise can reduce your risk of developing Alzheimer’s disease by up to 50 percent. What’s more, exercise can also slow further deterioration in those who have already started to develop cognitive problems. Exercise protects against Alzheimer’s and other types of dementia by stimulating the brain’s ability to maintain old connections as well as make new ones. Memory loss worries many of us as we get older. You might wonder whether you’ll become one of the 10 million baby boomers who develops Alzheimer’s disease. Or, maybe you’re simply seeking ways to fortify your memory with memory supplements, memory vitamins, or memory games. Will some of these brain boosters really help our memory?
Finding new ways to slow memory loss could produce astounding results. For example, if the onset of Alzheimer’s could be delayed in today’s population by an average of just one year, there would be about 210,000 fewer people with Alzheimer’s 10 years from now. And that would produce a cost savings of $10 billion.
“The problem with prescription drugs is that they’re extremely expensive and often have limited effectiveness during a short window of time,” says Evangeline Lausier, MD, assistant clinical professor in medicine, Duke Integrative Medicine, Duke University Medical Center in Durham, N.C.
Although there are a variety of “brain boosters” on the market — many chockfull of multiple substances — most are lacking research to support their memory-enhancing claims.
Ginkgo biloba is one that shows more promise than many others and is commonly used in Europe for a type of dementia resulting from reduced bloodflow, Lausier says. “Ginkgo biloba tends to improve blood flow in small vessels.”
“A couple of meta-analyses and systematic reviews show that ginkgo biloba is helpful for dementia in about the same range as drugs being pushed very heavily to treat Alzheimer’s,” says Adriane Fugh-Berman, MD, an associate professor in the complementary and alternative medicine Master’s program of the department of physiology and biophysics at Georgetown University School of Medicine.
Unfortunately, that’s not all that successful, she adds. Ginkgo doesn’t seem to help prevent dementia. But in people who already have dementia, it may either improve symptoms or stabilize symptoms so that they don’t get worse. In addition, some but not all studies show benefits in mood, alertness, and mental ability in healthy people who take ginkgo. More research needs to be done to be certain about these effects.
• Omega-3 fatty acid. Omega-3 fish oil supplements have piqued great interest. Studies suggest that a higher intake of omega-3 fatty acid from foods such as cold-water fish, plant and nut oils, and English walnuts are strongly linked to a lower risk of Alzheimer’s. However, thorough studies comparing omega-3s to placebo are needed to prove this memory benefit from supplements.
• Huperzine A. Also known as Chinese club moss, this natural medicine works in a similar way as Alzheimer’s drugs. But more evidence is needed to confirm its safety and effectiveness.
• Acetyl-L-carnitine. Some studies suggest that this amino acid might help Alzheimer’s patients with memory problems. It may provide a greater benefit to people with early onset and a fast rate of the disease.
• Vitamin E. Although vitamin E apparently doesn’t decrease the risk of developing Alzheimer’s, it may slow its progression. Recent studies have raised concerns about an increased risk of deaths in unhealthy people who take high doses of vitamin E, so be sure to consult with your doctor before taking this supplement.
• Asian (or Panax) ginseng. An herb that’s sometimes used with ginkgo biloba, Asian ginseng may help with fatigue and quality of life, Fugh-Berman tells WebMD. But any benefit for memory, she says, has shown up mostly in a small group or subset of study participants.